Bela prah 300/800 A TU/G Hirudin v prahu
1. Uvod Hirudin v prahu:
Hirudinski prah je najbolj aktiven in dobro raziskan od številnih aktivnih sestavin, ki so bile izvlečene iz pijavk in njihovih slinavk, in je majhen protein (peptid), sestavljen iz 65-66 aminokislin. Hirudin ima močan zaviralni učinek na trombin in je najmočnejši naravni specifični zaviralec trombina do zdaj.
2 ． Basic Information ：
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Product Name
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Hirudin
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Specification
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300/800 ATU/G
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Appearance
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White powder
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CAS No.
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113274-56-9
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Molecular formula
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C66H93N13O25
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Molecular weight
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1468.52
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Boiling point
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1913.6±65.0 °C(Predicted)
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Density
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1.384±0.06 g/cm3(Predicted)
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3. Delovanje
Anticoagulant effect
Hirudin has a highly specific and efficient inhibitory effect on thrombin, which can directly inhibit thrombin and impede the protein hydrolysis function of thrombin, so it has an anticoagulant effect. V primerjavi s heparinom je odmerjanje hirudina majhen, ne povzroča krvavitve in ni odvisen od endogenih kofaktorjev
Anti-thrombotic effects
Improving microcirculation and promoting metabolism
It can reduce the inflammatory reaction and edema around the brain tissue, relieve the rise of intracranial pressure, improve the local circulation, and facilitate the recovery of neurological function; it can also promote the absorption of experimental hematoma in the ear.
Improvement of cholesterol and triglycerides
Leech has a significant lowering effect on cholesterol and triglycerides in experimental hyperlipidemia. Hirudin has an inhibitory effect on tumor cells and has an inhibitory effect on liver cancer growth. Zaradi visokega antikoagulantnega učinka Leech olajša infiltracijo zdravil proti raku in imunološko aktivne celice v rakava tkiva, da ubijejo rakave celice.
Anti-myocardial ischemia and tardive dyskinesia
Its aqueous extract has significant antagonistic effect on acute myocardial ischemia and arrhythmia; Intraperitonealna injekcija leehina lahko poveča prehranski pretok krvi. Raztopina hirudina s sedacijo lahko spodbudi in zmanjša atrijsko fibrilacijo in periferni vnetni odziv, podobni rezultati pa so bili ugotovljeni v poskusih na podkožnem hematomu.
Effects on diabetes mellitus and its complications
Insulin resistance is prevalent in patients with type Il diabetes, accounting for almost 90% or more. Hirudin lahko deluje kot inzulinski senzibilizator, ki lahko poveča občutljivost telesa na svoj inzulin, in to je lasten inzulin, ki ga je mogoče oživiti, da v celoti deluje in zniža krvni sladkor; Sladkorna bolezen lahko uniči vse stene krvnih žil, ustvari vnetne reakcije in tvori krvne strdke, kar vodi do nekroze oči, ledvic in spodnjih okončin itd. Hirudin lahko zmanjša vnetno reakcijo stene krvnih žil in prepreči trombozo.
4. Application
Hirudin powder is a promising class of anticoagulant and anti-stasis drug, which can be used in the treatment of various thrombotic diseases, especially venous thrombosis and diffuse vascular coagulation; it can also be used to prevent the formation of arterial thrombosis after surgery, to prevent the formation of thrombus after dissolution of thrombus or after revascularization; Za izboljšanje ekstrakorporalnega obtoka in procesa hemodialize. In microsurgery, which often fails due to vascular embolism at the anastomosis, the use of hirudin can promote wound healing. Research has also shown that hirudin can play a role in tumor treatment. It stops the metastasis of tumor cells and has proven efficacy in tumors such as fibrosarcoma, osteosarcoma, angiosarcoma, melanoma and leukemia. Hirudin can also be used in conjunction with chemotherapy and radiation therapy to enhance the efficacy of treatment due to the promotion of blood flow in the tumor.
5. Coa
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Product Name
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Freeze-dried powder of Pheasant leech
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Inspection basis
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AJI92
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Batch No.
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SOST20220827
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Quantity
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1000Kg
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Manufacturing Date
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20220827
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Expiry Date
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20240826
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Based on test
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A leech from the 2020 edition of Chinese
Pharmacopoeia
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Sample status
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Powder
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Items
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Unit
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Testing result
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Test method
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Hirudin (antithrombin activity)
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ATU/G
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387.6
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A leech from the 2020 edition of Chinese
Pharmacopoeia
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Kategorije izdelkov : Vroče prodaja izdelkov
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